InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gclc

Summary

InnateDB Protein

IDBP-186030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gclc

Protein Name

glutamate-cysteine ligase, catalytic subunit

Synonyms

D9Wsu168e; Ggcs-hs; GLCL-H; Glclc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034905

InnateDB Gene

IDBG-186028 (Gclc)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004357	glutamate-cysteine ligase activity
GO:0005524	ATP binding
GO:0016595	glutamate binding
GO:0043531	ADP binding
GO:0046982	protein heterodimerization activity
GO:0050662	coenzyme binding

Biological Process

GO:0006534	cysteine metabolic process
GO:0006536	glutamate metabolic process
GO:0006749	glutathione metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0009408	response to heat
GO:0009410	response to xenobiotic stimulus
GO:0009725	response to hormone
GO:0019852	L-ascorbic acid metabolic process
GO:0031397	negative regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045454	cell redox homeostasis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046685	response to arsenic-containing substance
GO:0050880	regulation of blood vessel size
GO:0051409	response to nitrosative stress
GO:0051900	regulation of mitochondrial depolarization
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway