InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gclc

Summary

InnateDB Gene

IDBG-186028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gclc

Gene Name

glutamate-cysteine ligase, catalytic subunit

Synonyms

D9Wsu168e; Ggcs-hs; GLCL-H; Glclc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032350

Encoded Proteins

IDBP-186030

glutamate-cysteine ligase, catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000001084:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:77754535-77794485

Strand

Forward strand

Band

Transcripts

ENSMUST00000034905

ENSMUSP00000034905

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004357	glutamate-cysteine ligase activity
GO:0005524	ATP binding
GO:0016595	glutamate binding
GO:0043531	ADP binding
GO:0046982	protein heterodimerization activity
GO:0050662	coenzyme binding

Biological Process

GO:0006534	cysteine metabolic process
GO:0006536	glutamate metabolic process
GO:0006749	glutathione metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0009408	response to heat
GO:0009410	response to xenobiotic stimulus
GO:0009725	response to hormone
GO:0019852	L-ascorbic acid metabolic process
GO:0031397	negative regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045454	cell redox homeostasis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046685	response to arsenic-containing substance
GO:0050880	regulation of blood vessel size
GO:0051409	response to nitrosative stress
GO:0051900	regulation of mitochondrial depolarization
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway