InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polh

Summary

InnateDB Protein

IDBP-186159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polh

Protein Name

polymerase (DNA directed), eta (RAD 30 related)

Synonyms

RAD30A; XPV;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024749

InnateDB Gene

IDBG-186157 (Polh)

Protein Structure

UniProt Annotation

Function

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Accumulates at replication forks after DNA damage. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10871396}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000731	DNA synthesis involved in DNA repair
GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair
GO:0006290	pyrimidine dimer repair
GO:0006301	postreplication repair
GO:0010225	response to UV-C

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1891457

InterPro

IPR001126 DNA-repair protein, UmuC-like
IPR017061 DNA polymerase eta
IPR017961 DNA polymerase, Y-family, little finger domain
IPR017963 DNA-repair protein, UmuC-like, N-terminal

PFAM

PF00817
PF11799

PRINTS

PIRSF

PIRSF036603

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JJN0