InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAM2

Summary

InnateDB Protein

IDBP-18634.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM2

Protein Name

ADAM metallopeptidase domain 2

Synonyms

CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30; PH30-beta;

Species

Homo sapiens

Ensembl Protein

ENSP00000343854

InnateDB Gene

IDBG-18630 (ADAM2)

Protein Structure

UniProt Annotation

Function

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005178	integrin binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0007342	fusion of sperm to egg plasma membrane
GO:0032504	multicellular organism reproduction

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt