Version 5.4
Homo sapiens Gene: ADAM2
Summary
InnateDB Gene IDBG-18630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM2
Gene Name ADAM metallopeptidase domain 2
Synonyms CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30; PH30-beta
Species Homo sapiens
Ensembl Gene ENSG00000104755
Encoded Proteins
IDBP-18632
ADAM metallopeptidase domain 2
IDBP-18634
ADAM metallopeptidase domain 2
IDBP-18636
ADAM metallopeptidase domain 2
IDBP-485101
ADAM metallopeptidase domain 2
IDBP-809746
ADAM metallopeptidase domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. [provided by RefSeq, Jul 2008]
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:39743735-39838289
Strand Reverse strand
Band p11.22
Transcripts
ENST00000265708 ENSP00000265708
ENST00000347580 ENSP00000343854
ENST00000379853 ENSP00000369182
ENST00000521880 ENSP00000429352
ENST00000520434
ENST00000523181
ENST00000622267 ENSP00000483607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0007342 fusion of sperm to egg plasma membrane
GO:0008542 visual learning
GO:0030534 adult behavior
GO:0032504 multicellular organism reproduction
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022039
View Gene Order
ENSBTAG00000009408
Not yet available
Pathways
NETPATH
REACTOME
REACT_163933
Interaction With The Zona Pellucida pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001278113 NM_001278114 NM_001464
HUGO
OMIM
CCDS CCDS34884 CCDS64882 CCDS64883
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca