InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Inpp5b

Summary

InnateDB Protein

IDBP-186728.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inpp5b

Protein Name

inositol polyphosphate-5-phosphatase B

Synonyms

75kDa; AW260155; INPP5P;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092375

InnateDB Gene

IDBG-186724 (Inpp5b)

Protein Structure

UniProt Annotation

Function

Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269PubMed:11311145, ECO:0000269PubMed:9525932}.

Subcellular Localization

Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment {ECO:0000250}. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane. Golgi apparatus {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in kidney, liver, brain, lung and testis (at protein level). Detected in kidney and liver, and at lower levels in brain, lung and testis. {ECO:0000269PubMed:9525932}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0030317	sperm motility
GO:0046856	phosphatidylinositol dephosphorylation
GO:0070613	regulation of protein processing

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

MGI:103257

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR000300 Inositol polyphosphate-related phosphatase
IPR005135 Endonuclease/exonuclease/phosphatase
IPR008936 Rho GTPase activation protein

PFAM

PF00620
PF03372
PF14529

PRINTS

PIRSF

SMART

SM00324
SM00128

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K337