InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Inpp5b

Summary

InnateDB Gene

IDBG-186724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inpp5b

Gene Name

inositol polyphosphate-5-phosphatase B

Synonyms

75kDa; AW260155; INPP5P

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028894

Encoded Proteins

IDBP-186728

inositol polyphosphate-5-phosphatase B

IDBP-536841

inositol polyphosphate-5-phosphatase B

IDBP-542397

inositol polyphosphate-5-phosphatase B

IDBP-788254

inositol polyphosphate-5-phosphatase B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204084:
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:124741850-124801511

Strand

Forward strand

Band

D2.2

Transcripts

ENSMUST00000094782	ENSMUSP00000092375
ENSMUST00000153837	ENSMUSP00000122568
ENSMUST00000154229	ENSMUSP00000115176
ENSMUST00000145359
ENSMUST00000142652
ENSMUST00000135971
ENSMUST00000142446
ENSMUST00000184454	ENSMUSP00000139221

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0030317	sperm motility
GO:0046856	phosphatidylinositol dephosphorylation
GO:0070613	regulation of protein processing

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0031901	early endosome membrane