InnateDB Protein
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IDBP-186787.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sort1
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Protein Name
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sortilin 1
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Synonyms
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2900053A11Rik; AI852375; Ntr3; Ntsr3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099692
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InnateDB Gene
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IDBG-186785 (Sort1)
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Protein Structure
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Function |
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269PubMed:10594043, ECO:0000269PubMed:15236332, ECO:0000269PubMed:15236333, ECO:0000269PubMed:15372498, ECO:0000269PubMed:15992544, ECO:0000269PubMed:19407813, ECO:0000269PubMed:21102451}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. Interaction with NRADD promotes localization at the cell membrane in neurons; this promotes interaction with NGFR. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes is enhanced by insulin.
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Disease Associations |
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Tissue Specificity |
Expressed in the brain, particularly the piriform cortex, the cerebral cortex and the hippocampus. {ECO:0000269PubMed:10064893}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1338015
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InterPro |
IPR002860
BNR repeat
IPR006581
VPS10
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PFAM |
PF02012
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PRINTS |
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PIRSF |
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SMART |
SM00602
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PHU5
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PhosphoSite |
PhosphoSite-Q6PHU5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20661
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UniGene |
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RefSeq |
NP_064356
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MGI ID |
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MGI Symbol |
Sort1
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OMIM |
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CCDS |
CCDS17756
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HPRD |
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IMGT |
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EMBL |
AF175279
AK147442
AL671899
BC034129
BC056343
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GenPept |
AAF22639
AAH34129
AAH56343
BAE27915
CAM19473
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