InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sort1

Summary

InnateDB Gene

IDBG-186785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sort1

Gene Name

sortilin 1

Synonyms

2900053A11Rik; AI852375; Ntr3; Ntsr3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068747

Encoded Proteins

IDBP-186787

sortilin 1

IDBP-532050

sortilin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134243:
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:108284091-108361511

Strand

Forward strand

Band

F2.3

Transcripts

ENSMUST00000102632	ENSMUSP00000099692
ENSMUST00000135636	ENSMUSP00000123564
ENSMUST00000129755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0010465	nerve growth factor receptor activity
GO:0019899	enzyme binding
GO:0030379	neurotensin receptor activity, non-G-protein coupled
GO:0048406	nerve growth factor binding

Biological Process

GO:0001503	ossification
GO:0006810	transport
GO:0006895	Golgi to endosome transport
GO:0006897	endocytosis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007275	multicellular organismal development
GO:0008333	endosome to lysosome transport
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010468	regulation of gene expression
GO:0014902	myotube differentiation
GO:0016050	vesicle organization
GO:0032509	endosome transport via multivesicular body sorting pathway
GO:0032868	response to insulin
GO:0038180	nerve growth factor signaling pathway
GO:0046323	glucose import
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048227	plasma membrane to endosome transport
GO:0051005	negative regulation of lipoprotein lipase activity

Cellular Component

GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030136	clathrin-coated vesicle
GO:0030140	trans-Golgi network transport vesicle
GO:0031965	nuclear membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm