InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbfb

Summary

InnateDB Protein

IDBP-186826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbfb

Protein Name

core binding factor beta

Synonyms

AI893578; PEA2; Pebp2; PEBP2b; Pebpb2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059382

InnateDB Gene

IDBG-186824 (Cbfb)

Protein Structure

UniProt Annotation

Function

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested. Highest level in thymus, but also abundantly expressed in muscle, lung and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0030098	lymphocyte differentiation
GO:0030099	myeloid cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0060216	definitive hemopoiesis