InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plxnc1

Summary

InnateDB Protein

IDBP-186906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plxnc1

Protein Name

plexin C1

Synonyms

2510048K12Rik; AW742158; CD232; Vespr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096939

InnateDB Gene

IDBG-186904 (Plxnc1)

Protein Structure

UniProt Annotation

Function

Receptor for SEMA7A, for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected on dendritic cells, skin Langerhans cells and neutrophils (at protein level). {ECO:0000269PubMed:15611227}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007275	multicellular organismal development

Cellular Component

GO:0005622	intracellular
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1890127

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZC2