InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tradd

Summary

InnateDB Protein

IDBP-186920.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tradd

Protein Name

TNFRSF1A-associated via death domain

Synonyms

9130005N23Rik; AA930854;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034359

InnateDB Gene

IDBG-186918 (Tradd)

Protein Structure

UniProt Annotation

Function

Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. {ECO:0000250, ECO:0000269PubMed:22561347}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	81 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0060090	binding, bridging
GO:0070513	death domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051291	protein heterooligomerization
GO:0051798	positive regulation of hair follicle development
GO:0097191	extrinsic apoptotic signaling pathway