InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psrc1

Summary

InnateDB Protein

IDBP-186975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psrc1

Protein Name

proline/serine-rich coiled-coil 1

Synonyms

5430413I02Rik; AL033312; Dda3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088049

InnateDB Gene

IDBG-186971 (Psrc1)

Protein Structure

UniProt Annotation

Function

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12427559}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:12427559}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, brain and lung. Weaker expression in kidney and testis. {ECO:0000269PubMed:10618717}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0001578	microtubule bundle formation
GO:0007080	mitotic metaphase plate congression
GO:0009987	cellular process
GO:0030308	negative regulation of cell growth
GO:0031116	positive regulation of microtubule polymerization
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060236	regulation of mitotic spindle organization

Cellular Component

GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton
GO:0030496	midbody