Version 5.4
Mus musculus Gene: Psrc1
Summary
InnateDB Gene IDBG-186971.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psrc1
Gene Name proline/serine-rich coiled-coil 1
Synonyms 5430413I02Rik; AL033312; Dda3
Species Mus musculus
Ensembl Gene ENSMUSG00000068744
Encoded Proteins
IDBP-186975
proline/serine-rich coiled-coil 1
IDBP-186977
proline/serine-rich coiled-coil 1
IDBP-541539
proline/serine-rich coiled-coil 1
IDBP-534980
proline/serine-rich coiled-coil 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134222:
This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:108383839-108388231
Strand Forward strand
Band F3
Transcripts
ENSMUST00000090561 ENSMUSP00000088049
ENSMUST00000102629 ENSMUSP00000099689
ENSMUST00000133405
ENSMUST00000130906
ENSMUST00000126461
ENSMUST00000128089 ENSMUSP00000115634
ENSMUST00000145141
ENSMUST00000143309
ENSMUST00000148509 ENSMUSP00000120482
ENSMUST00000128962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0001578 microtubule bundle formation
GO:0007080 mitotic metaphase plate congression
GO:0009987 cellular process
GO:0030308 negative regulation of cell growth
GO:0031116 positive regulation of microtubule polymerization
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060236 regulation of mitotic spindle organization
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134222
View Gene Order
ENSBTAG00000018806
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.389499
RefSeq NM_001190161 NM_019976
OMIM
CCDS CCDS17758
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca