InnateDB Protein
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IDBP-186977.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Psrc1
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Protein Name
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proline/serine-rich coiled-coil 1
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Synonyms
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5430413I02Rik; AL033312; Dda3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099689
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InnateDB Gene
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IDBG-186971 (Psrc1)
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Protein Structure
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Function |
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12427559}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:12427559}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart, brain and lung. Weaker expression in kidney and testis. {ECO:0000269PubMed:10618717}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0001578
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microtubule bundle formation
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GO:0007080
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mitotic metaphase plate congression
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GO:0009987
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cellular process
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GO:0030308
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negative regulation of cell growth
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GO:0031116
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positive regulation of microtubule polymerization
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GO:0045737
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positive regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0060236
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regulation of mitotic spindle organization
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Cellular Component |
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PDB ID |
MGI:1913099
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D0P7
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PhosphoSite |
PhosphoSite-Q9D0P7
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TrEMBL |
Q8BT87
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UniProt Splice Variant |
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Entrez Gene |
56742
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UniGene |
Mm.389499
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RefSeq |
NP_001177090
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MGI ID |
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MGI Symbol |
Psrc1
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OMIM |
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CCDS |
CCDS17758
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HPRD |
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IMGT |
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EMBL |
AF156598
AF284692
AF322890
AK011197
AK012815
AK012895
AK017302
AK041835
AK167415
BC019165
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GenPept |
AAF24174
AAH19165
AAM45430
AAN73433
BAB27461
BAB30682
BAC25380
BAC25381
BAC31079
BAE39503
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