InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ldhc

Summary

InnateDB Protein

IDBP-187012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ldhc

Protein Name

lactate dehydrogenase C

Synonyms

Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014545

InnateDB Gene

IDBG-187010 (Ldhc)

Protein Structure

UniProt Annotation

Function

Possible role in sperm motility. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed within the midpiece of sperm tail (at protein level). {ECO:0000269PubMed:23055941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004459	L-lactate dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006090	pyruvate metabolic process
GO:0006096	glycolytic process
GO:0006754	ATP biosynthetic process
GO:0019244	lactate biosynthetic process from pyruvate
GO:0019516	lactate oxidation
GO:0030317	sperm motility
GO:0044262	cellular carbohydrate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005929	cilium
GO:0031514	motile cilium

Protein Structure and Domains

PDB ID

MGI:96764

InterPro

IPR001236 Lactate/malate dehydrogenase, N-terminal
IPR001557 L-lactate/malate dehydrogenase
IPR011304 L-lactate dehydrogenase
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR022383 Lactate/malate dehydrogenase, C-terminal

PFAM

PF00056
PF02866

PRINTS

PR00086

PIRSF

PIRSF000102

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt