InnateDB Protein
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IDBP-187021.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc17a5
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Protein Name
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solute carrier family 17 (anion/sugar transporter), member 5
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000056182
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InnateDB Gene
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IDBG-187019 (Slc17a5)
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Protein Structure
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Function |
Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0015136
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sialic acid transmembrane transporter activity
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GO:0015293
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symporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1924105
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InterPro |
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
IPR020846
Major facilitator superfamily domain
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PFAM |
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BN82
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PhosphoSite |
PhosphoSite-Q8BN82
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
235504
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UniGene |
Mm.46932
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RefSeq |
NP_766361
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MGI ID |
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MGI Symbol |
Slc17a5
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OMIM |
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CCDS |
CCDS23364
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HPRD |
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IMGT |
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EMBL |
AK029102
AK087395
AK169868
BC058785
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GenPept |
AAH58785
BAC26298
BAC39859
BAE41423
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