InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATG7

Summary

InnateDB Protein

IDBP-18706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATG7

Protein Name

ATG7 autophagy related 7 homolog (S. cerevisiae)

Synonyms

APG7-LIKE; APG7L; GSA7;

Species

Homo sapiens

Ensembl Protein

ENSP00000346437

InnateDB Gene

IDBG-18704 (ATG7)

Protein Structure

UniProt Annotation

Function

E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. {ECO:0000269PubMed:11096062, ECO:0000269PubMed:16303767, ECO:0000269PubMed:22170151}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. {ECO:0000269PubMed:11890701}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019778	Atg12 activating enzyme activity
GO:0019779	Atg8 activating enzyme
GO:0042803	protein homodimerization activity

Biological Process

GO:0000422	mitochondrion degradation
GO:0001889	liver development
GO:0006464	cellular protein modification process
GO:0006497	protein lipidation
GO:0006501	C-terminal protein lipidation
GO:0006520	cellular amino acid metabolic process
GO:0006914	autophagy
GO:0006995	cellular response to nitrogen starvation
GO:0006996	organelle organization
GO:0007005	mitochondrion organization
GO:0007628	adult walking behavior
GO:0009267	cellular response to starvation
GO:0009791	post-embryonic development
GO:0010508	positive regulation of autophagy
GO:0015031	protein transport
GO:0016239	positive regulation of macroautophagy
GO:0016567	protein ubiquitination
GO:0021680	cerebellar Purkinje cell layer development
GO:0021860	pyramidal neuron development
GO:0021955	central nervous system neuron axonogenesis
GO:0021987	cerebral cortex development
GO:0030163	protein catabolic process
GO:0031175	neuron projection development
GO:0031396	regulation of protein ubiquitination
GO:0031401	positive regulation of protein modification process
GO:0032446	protein modification by small protein conjugation
GO:0034727	piecemeal microautophagy of nucleus
GO:0039689	negative stranded viral RNA replication
GO:0042594	response to starvation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044805	late nucleophagy
GO:0045732	positive regulation of protein catabolic process
GO:0050877	neurological system process
GO:0055013	cardiac muscle cell development
GO:0061024	membrane organization
GO:0061025	membrane fusion
GO:0071455	cellular response to hyperoxia

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005930	axoneme

Protein Structure and Domains

PDB ID

InterPro

IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR006285 Ubiquitin-like modifier-activating enzyme Atg7
IPR009036 Molybdenum cofactor biosynthesis, MoeB

PFAM

PF00899

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95352

PhosphoSite