Version 5.4
Homo sapiens Gene: ATG7
Summary
InnateDB Gene IDBG-18704.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG7
Gene Name autophagy related 7
Synonyms APG7-LIKE; APG7L; GSA7
Species Homo sapiens
Ensembl Gene ENSG00000197548
Encoded Proteins
IDBP-18706
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-18708
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363407
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363494
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363497
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363501
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363506
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363511
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363514
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363518
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363521
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363523
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363524
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363525
ATG7 autophagy related 7 homolog (S. cerevisiae)
IDBP-363526
ATG7 autophagy related 7 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25512546
[Mus musculus] Atg7 plays an essential role for autophagy during invariant natural killer T cell development.
Entrez Gene
Summary This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:11272309-11557665
Strand Forward strand
Band p25.3
Transcripts
ENST00000354449 ENSP00000346437
ENST00000354956 ENSP00000347042
ENST00000451513 ENSP00000415223
ENST00000446450 ENSP00000412580
ENST00000451830 ENSP00000411880
ENST00000435760 ENSP00000390547
ENST00000444619 ENSP00000389996
ENST00000418682 ENSP00000389012
ENST00000419112 ENSP00000408303
ENST00000423116 ENSP00000416644
ENST00000424071 ENSP00000409844
ENST00000434066 ENSP00000393075
ENST00000414717 ENSP00000407340
ENST00000427759 ENSP00000388295
ENST00000446110 ENSP00000406398
ENST00000460444
ENST00000470474
ENST00000469654
ENST00000488924
ENST00000464282
ENST00000478638
ENST00000461278
ENST00000460291
ENST00000467121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004839 ubiquitin activating enzyme activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019778 Atg12 activating enzyme activity
GO:0019779 Atg8 activating enzyme
GO:0042803 protein homodimerization activity
Biological Process
GO:0000422 mitochondrion degradation
GO:0001889 liver development
GO:0006464 cellular protein modification process
GO:0006497 protein lipidation
GO:0006501 C-terminal protein lipidation
GO:0006520 cellular amino acid metabolic process
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0006996 organelle organization
GO:0007005 mitochondrion organization
GO:0007628 adult walking behavior
GO:0009267 cellular response to starvation
GO:0009791 post-embryonic development
GO:0010508 positive regulation of autophagy
GO:0015031 protein transport
GO:0016239 positive regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0021680 cerebellar Purkinje cell layer development
GO:0021860 pyramidal neuron development
GO:0021955 central nervous system neuron axonogenesis
GO:0021987 cerebral cortex development
GO:0030163 protein catabolic process
GO:0031175 neuron projection development
GO:0031396 regulation of protein ubiquitination
GO:0031401 positive regulation of protein modification process
GO:0032446 protein modification by small protein conjugation
GO:0034727 piecemeal microautophagy of nucleus
GO:0039689 negative stranded viral RNA replication
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044805 late nucleophagy
GO:0045732 positive regulation of protein catabolic process
GO:0050877 neurological system process
GO:0055013 cardiac muscle cell development
GO:0061024 membrane organization
GO:0061025 membrane fusion
GO:0071455 cellular response to hyperoxia
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005930 axoneme
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030314
View Gene Order
ENSBTAG00000035827
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10533
UniGene Hs.38032 Hs.629433
RefSeq NM_001136031 NM_001144912 NM_006395 XM_005264803 XM_006712931 XM_006712934 XM_006712935
HUGO HGNC:16935
OMIM 608760
CCDS CCDS2605 CCDS46752 CCDS46753
HPRD 12293
IMGT
EMBL
GenPept
RNA Seq Atlas 10533

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca