InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cradd

Summary

InnateDB Protein

IDBP-187070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cradd

Protein Name

CASP2 and RIPK1 domain containing adaptor with death domain

Synonyms

RAIDD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050295

InnateDB Gene

IDBG-187068 (Cradd)

Protein Structure

UniProt Annotation

Function

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22279524}. Nucleus {ECO:0000269PubMed:22279524}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0070513	death domain binding

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165	signal transduction
GO:0042981	regulation of apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:2001235	positive regulation of apoptotic signaling pathway