InnateDB Protein
|
IDBP-18708.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ATG7
|
Protein Name
|
ATG7 autophagy related 7 homolog (S. cerevisiae)
|
Synonyms
|
APG7-LIKE; APG7L; GSA7;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000347042
|
InnateDB Gene
|
IDBG-18704 (ATG7)
|
Protein Structure
|
|
Function |
E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. {ECO:0000269PubMed:11096062, ECO:0000269PubMed:16303767, ECO:0000269PubMed:22170151}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. {ECO:0000269PubMed:11890701}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
|
Protein-Protein |
51
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
8 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000594
UBA/THIF-type NAD/FAD binding fold
IPR006285
Ubiquitin-like modifier-activating enzyme Atg7
IPR009036
Molybdenum cofactor biosynthesis, MoeB
|
PFAM |
PF00899
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O95352
|
PhosphoSite |
PhosphoSite-O95352
|
TrEMBL |
H7C059
|
UniProt Splice Variant |
|
Entrez Gene |
10533
|
UniGene |
Hs.629433
|
RefSeq |
NP_001129503
|
HUGO |
HGNC:16935
|
OMIM |
608760
|
CCDS |
CCDS46752
|
HPRD |
12293
|
IMGT |
|
EMBL |
AC020750
AC022001
AC026185
AC083855
AF094516
AK303694
AL122075
BC000091
|
GenPept |
AAC69630
AAH00091
BAG64682
CAB59250
|
|
|