Version 5.4
Mus musculus Protein: Cd109
Summary
InnateDB Protein IDBP-187098.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd109
Protein Name CD109 antigen
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000091330
InnateDB Gene IDBG-187096 (Cd109)
Protein Structure
UniProt Annotation
Function Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061045 negative regulation of wound healing
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID MGI:2445221
InterPro IPR001599 Alpha-2-macroglobulin
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
PFAM PF00207
PF01835
PF07677
PF07703
PF07678
PF10569
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R422
PhosphoSite PhosphoSite-Q8R422
TrEMBL A6MDD3
UniProt Splice Variant
Entrez Gene 235505
UniGene Mm.32955
RefSeq NP_694738
MGI ID
MGI Symbol Cd109
OMIM
CCDS CCDS23365
HPRD
IMGT
EMBL AK042169 AY083458 BC052443 CH466522 DQ832284
GenPept AAH52443 AAM00021 ABI30218 BAC31190 EDL26409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca