Version 5.4
Mus musculus Gene: Cd109
Summary
InnateDB Gene IDBG-187096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd109
Gene Name CD109 antigen
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000046186
Encoded Proteins
IDBP-187098
CD109 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156535:
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:78615546-78716253
Strand Forward strand
Band E1
Transcripts
ENSMUST00000093812 ENSMUSP00000091330
ENSMUST00000163608
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061045 negative regulation of wound healing
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000156535
View Gene Order
ENSBTAG00000013222
Not yet available
Cross-References
SwissProt Q8R422
TrEMBL A6MDD3
UniProt Splice Variant
Entrez Gene 235505
UniGene Mm.32955
RefSeq NM_153098
OMIM
CCDS CCDS23365
HPRD
IMGT
MGI ID MGI:2445221
MGI Symbol Cd109
EMBL AK042169 AY083458 BC052443 CH466522 DQ832284
GenPept AAH52443 AAM00021 ABI30218 BAC31190 EDL26409
RNA Seq Atlas 235505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca