InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHIC2

Summary

InnateDB Protein

IDBP-18716.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHIC2

Protein Name

cysteine-rich hydrophobic domain 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263921

InnateDB Gene

IDBG-18712 (CHIC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11257495}. Cytoplasmic vesicle {ECO:0000269PubMed:11257495}. Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles.

Disease Associations

Note=A chromosomal aberration involving CHIC2 is found in a form of acute myeloid leukemia (AML). Translocation t(4;12)(q12;p13) with ETV6.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005575	cellular_component
GO:0005794	Golgi apparatus
GO:0005798	Golgi-associated vesicle
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR019383 Golgin subfamily A member 7/ERF4

PFAM

PF10256

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UKJ5

PhosphoSite

PhosphoSite-Q9UKJ5

TrEMBL

UniProt Splice Variant

Entrez Gene

26511

UniGene

Hs.712904

RefSeq

NP_036242

HUGO

HGNC:1935

OMIM

604332

CCDS

CCDS3493

HPRD

10373

IMGT

EMBL

AF159423 AK312427 BC034691 CH471057

GenPept

AAD55981 AAH34691 BAG35336 EAX05453