InnateDB Protein
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IDBP-187169.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ube2n
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Protein Name
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ubiquitin-conjugating enzyme E2N
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Synonyms
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1500026J17Rik; AL022654; BB101821; UBC13;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000096932
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InnateDB Gene
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IDBG-187167 (Ube2n)
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Protein Structure
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Function |
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD (By similarity). Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 114 interaction(s) predicted by orthology.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
114 [view]
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Molecular Function |
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Biological Process |
GO:0000724
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double-strand break repair via homologous recombination
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GO:0000729
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DNA double-strand break processing
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GO:0006301
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postreplication repair
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0016567
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protein ubiquitination
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GO:0016574
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histone ubiquitination
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GO:0031058
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positive regulation of histone modification
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GO:0033182
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regulation of histone ubiquitination
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0045739
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positive regulation of DNA repair
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GO:0050852
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T cell receptor signaling pathway
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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GO:0051443
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positive regulation of ubiquitin-protein transferase activity
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GO:0070534
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protein K63-linked ubiquitination
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Cellular Component |
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PDB ID |
MGI:1934835
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61089
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PhosphoSite |
PhosphoSite-P61089
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TrEMBL |
A2RTT4
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UniProt Splice Variant |
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Entrez Gene |
93765
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UniGene |
Mm.486592
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RefSeq |
NP_542127
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MGI ID |
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MGI Symbol |
Ube2n
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OMIM |
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CCDS |
CCDS48677
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HPRD |
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IMGT |
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EMBL |
AK005302
AK005788
AK161968
AY039837
BC034898
BC067069
BC132630
BC138211
CH466539
Y09873
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GenPept |
AAH34898
AAH67069
AAI32631
AAI38212
AAK74128
BAB23941
BAB24239
BAE36659
CAA71001
EDL21609
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