InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eea1

Summary

InnateDB Protein

IDBP-187257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eea1

Protein Name

early endosome antigen 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061493

InnateDB Gene

IDBG-187255 (Eea1)

Protein Structure

UniProt Annotation

Function

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0030742	GTP-dependent protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006897	endocytosis
GO:0006906	vesicle fusion

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005969	serine-pyruvate aminotransferase complex
GO:0019897	extrinsic component of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0044308	axonal spine
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome