InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpn5

Summary

InnateDB Protein

IDBP-187288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn5

Protein Name

protein tyrosine phosphatase, non-receptor type 5

Synonyms

Step;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099686

InnateDB Gene

IDBG-187284 (Ptpn5)

Protein Structure

UniProt Annotation

Function

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000250}.

Subcellular Localization

Isoform STEP61: Endoplasmic reticulum membrane; Multi-pass membrane protein.Isoform STEP46: Cytoplasm.

Disease Associations

Tissue Specificity

STEP20 is expressed only in the CNS.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004725	protein tyrosine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:97807

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008356 Protein-tyrosine phosphatase, KIM-containing
IPR016334 Protein-tyrosine phosphatase, receptor type R/non-receptor type 5
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700
PR01778

PIRSF

PIRSF001997

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References