InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gli2

Summary

InnateDB Protein

IDBP-187321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gli2

Protein Name

GLI-Kruppel family member GLI2

Synonyms

AW546128;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054837

InnateDB Gene

IDBG-187317 (Gli2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element. Is involved in the smoothened (SHH) signaling pathway.

Subcellular Localization

Nucleus. Cytoplasm. Note=In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0002009	morphogenesis of an epithelium
GO:0002062	chondrocyte differentiation
GO:0002076	osteoblast development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007224	smoothened signaling pathway
GO:0007389	pattern specification process
GO:0007411	axon guidance
GO:0007418	ventral midline development
GO:0007442	hindgut morphogenesis
GO:0007507	heart development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008589	regulation of smoothened signaling pathway
GO:0009612	response to mechanical stimulus
GO:0009913	epidermal cell differentiation
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0021508	floor plate formation
GO:0021513	spinal cord dorsal/ventral patterning
GO:0021517	ventral spinal cord development
GO:0021522	spinal cord motor neuron differentiation
GO:0021696	cerebellar cortex morphogenesis
GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021904	dorsal/ventral neural tube patterning
GO:0021915	neural tube development
GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021965	spinal cord ventral commissure morphogenesis
GO:0021983	pituitary gland development
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0030879	mammary gland development
GO:0030902	hindbrain development
GO:0032331	negative regulation of chondrocyte differentiation
GO:0035295	tube development
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0045666	positive regulation of neuron differentiation
GO:0045740	positive regulation of DNA replication
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048566	embryonic digestive tract development
GO:0048589	developmental growth
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048666	neuron development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048856	anatomical structure development
GO:0060032	notochord regression
GO:0060322	head development
GO:0060513	prostatic bud formation
GO:0060603	mammary gland duct morphogenesis
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0071407	cellular response to organic cyclic compound
GO:0090103	cochlea morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005929	cilium
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0031512	motile primary cilium
GO:0072372	primary cilium
GO:0097542	ciliary tip