InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptk7

Summary

InnateDB Protein

IDBP-187404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptk7

Protein Name

PTK7 protein tyrosine kinase 7

Synonyms

8430404F20Rik; chz; mPTK7/CCK4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043703

InnateDB Gene

IDBG-187402 (Ptk7)

Protein Structure

UniProt Annotation

Function

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269PubMed:15229603, ECO:0000269PubMed:19439496, ECO:0000269PubMed:20704721}.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Cell junction {ECO:0000250}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Disease Associations

Tissue Specificity

Expressed at high levels in lung and un- pregnant uterus among adult tissues, and in the tail, limbs, somites, gut and craniofacial regions among embryonic tissues. {ECO:0000269PubMed:15019986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001736	establishment of planar polarity
GO:0001843	neural tube closure
GO:0003401	axis elongation
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0010976	positive regulation of neuron projection development
GO:0016477	cell migration
GO:0031532	actin cytoskeleton reorganization
GO:0042060	wound healing
GO:0045198	establishment of epithelial cell apical/basal polarity
GO:0060026	convergent extension
GO:0060070	canonical Wnt signaling pathway
GO:0060484	lung-associated mesenchyme development
GO:0071300	cellular response to retinoic acid
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1918711

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00406
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt