InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zc3h12a

Summary

InnateDB Protein

IDBP-187494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zc3h12a

Protein Name

zinc finger CCCH type containing 12A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037172

InnateDB Gene

IDBG-187492 (Zc3h12a)

Protein Structure

UniProt Annotation

Function

Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19322177}. Nucleus {ECO:0000250UniProtKB:Q5D1E8}.

Disease Associations

Tissue Specificity

Highly expressed in cardiac myocytes and in macrophages (at protein level). Detected in spleen, lung, intestine, brown adipose tissue and thymus. {ECO:0000269PubMed:16574901, ECO:0000269PubMed:18178554, ECO:0000269PubMed:18682727}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptotic process
GO:0010508	positive regulation of autophagy
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010884	positive regulation of lipid storage
GO:0030154	cell differentiation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045600	positive regulation of fat cell differentiation
GO:0071222	cellular response to lipopolysaccharide
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:2000379	positive regulation of reactive oxygen species metabolic process