InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zc3h12a

Summary

InnateDB Gene

IDBG-187492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zc3h12a

Gene Name

zinc finger CCCH type containing 12A

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042677

Encoded Proteins

IDBP-187494

zinc finger CCCH type containing 12A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22037600

Zc3h12a prevents autoimmunity by controlling the stability of cytokine mRNA, such as Il6. Zc3h12a protein degradation is facilitated by IKK complex, which acts downstream of TLR stimulation.

PMID 22777400

Zc3h12a is a potent regulator of innate immunity, which can be strongly engaged in the pathogenesis of acute and chronic infective diseases. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 22037600

[Homo sapiens] ZC3H12A prevents autoimmunity by controlling the stability of cytokine mRNA, such as IL6. ZC3H12A protein degradation is facilitated by IKK complex, which acts downstream of TLR stimulation. (Demonstrated in mice)

PMID 22777400

[Homo sapiens] ZC3H12A is a potent regulator of innate immunity, which can be strongly engaged in the pathogenesis of acute and chronic infective diseases.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163874:
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:125118423-125127840

Strand

Reverse strand

Band

D2.2

Transcripts

ENSMUST00000036188	ENSMUSP00000037172
ENSMUST00000131685

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptotic process
GO:0010508	positive regulation of autophagy
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010884	positive regulation of lipid storage
GO:0030154	cell differentiation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045600	positive regulation of fat cell differentiation
GO:0071222	cellular response to lipopolysaccharide
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000163874

View Gene Order

ENSBTAG00000011316

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.402

RefSeq

NM_153159

OMIM

CCDS

CCDS18638

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas