InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tenc1

Summary

InnateDB Protein

IDBP-187554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tenc1

Protein Name

tensin like C1 domain-containing phosphatase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041087

InnateDB Gene

IDBG-187550 (Tenc1)

Protein Structure

UniProt Annotation

Function

Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the end of actin stress fibers. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001822	kidney development
GO:0008285	negative regulation of cell proliferation
GO:0014850	response to muscle activity
GO:0016311	dephosphorylation
GO:0019725	cellular homeostasis
GO:0032963	collagen metabolic process
GO:0035264	multicellular organism growth
GO:0035556	intracellular signal transduction
GO:0048871	multicellular organismal homeostasis

Cellular Component

GO:0005886	plasma membrane
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

MGI:2387586

InterPro

IPR000008 C2 domain
IPR000980 SH2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
IPR014020 Tensin phosphatase, C2 domain
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain

PFAM