InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtf2

Summary

InnateDB Protein

IDBP-187574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtf2

Protein Name

metal response element binding transcription factor 2

Synonyms

9230112N11Rik; AA537621; C76717; M96; Pcl2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080278

InnateDB Gene

IDBG-187572 (Mtf2)

Protein Structure

UniProt Annotation

Function

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter. {ECO:0000269PubMed:20144788, ECO:0000269PubMed:21059868, ECO:0000269PubMed:21367819, ECO:0000269PubMed:9173905}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21367819}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007379	segment specification
GO:0016568	chromatin modification
GO:0019827	stem cell maintenance
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048863	stem cell differentiation
GO:0061086	negative regulation of histone H3-K27 methylation
GO:0061087	positive regulation of histone H3-K27 methylation