InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myh8

Summary

InnateDB Protein

IDBP-187766.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh8

Protein Name

myosin, heavy polypeptide 8, skeletal muscle, perinatal

Synonyms

4832426G23Rik; AI327267; MHCp; MyHC-pn; Myhs-p; Myhsp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019625

InnateDB Gene

IDBG-187764 (Myh8)

Protein Structure

UniProt Annotation

Function

Muscle contraction.

Subcellular Localization

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0000166	nucleotide binding
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0030049	muscle filament sliding

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005925	focal adhesion
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0032982	myosin filament

Protein Structure and Domains

PDB ID

MGI:1339712

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR009053 Prefoldin
IPR010978 tRNA-binding arm
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01576
PF02736

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt