Version 5.4
Mus musculus Gene: Myh8
Summary
InnateDB Gene IDBG-187764.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myh8
Gene Name myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms 4832426G23Rik; AI327267; MHCp; MyHC-pn; Myhs-p; Myhsp
Species Mus musculus
Ensembl Gene ENSMUSG00000055775
Encoded Proteins
IDBP-187766
myosin, heavy polypeptide 8, skeletal muscle, perinatal
IDBP-264012
myosin, heavy polypeptide 8, skeletal muscle, perinatal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67277124-67308634
Strand Forward strand
Band B3
Transcripts
ENSMUST00000019625 ENSMUSP00000019625
ENSMUST00000108686
ENSMUST00000108685 ENSMUSP00000104325
ENSMUST00000139052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006200 ATP catabolic process
GO:0008152 metabolic process
GO:0030049 muscle filament sliding
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0032982 myosin filament
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133020
View Gene Order
ENSBTAG00000009702
Not yet available
Pathways
NETPATH
REACTOME
REACT_232053
Striated Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt P13542
TrEMBL Q1WNQ0
UniProt Splice Variant
Entrez Gene 17885
UniGene Mm.340163 Mm.398862
RefSeq NM_177369
OMIM
CCDS CCDS24857
HPRD
IMGT
MGI ID MGI:1339712
MGI Symbol Myh8
EMBL AL596129 AY963802 DQ021876 DQ021877 DQ021878 DQ021879 M12289
GenPept AAA39795 AAY42748 AAY42757 AAY42758 AAY42759 AAY42760 CAI24991
RNA Seq Atlas 17885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca