InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eno2

Summary

InnateDB Protein

IDBP-187793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eno2

Protein Name

enolase 2, gamma neuronal

Synonyms

AI837106; D6Ertd375e; Eno-2; NSE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004378

InnateDB Gene

IDBG-187789 (Eno2)

Protein Structure

UniProt Annotation

Function

Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. {ECO:0000250}.

Disease Associations

Tissue Specificity

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004634	phosphopyruvate hydratase activity

Biological Process

GO:0006096

glycolytic process

Cellular Component

GO:0000015	phosphopyruvate hydratase complex
GO:0001917	photoreceptor inner segment
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95394

InterPro

IPR000941 Enolase
IPR020810 Enolase, C-terminal
IPR020811 Enolase, N-terminal
IPR022662 Methylaspartate ammonia-lyase, C-terminal
IPR029017 Enolase N-terminal domain-like
IPR029065 Enolase C-terminal domain-like

PFAM

PF00113
PF03952
PF07476

PRINTS

PR00148

PIRSF

PIRSF001400

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt