InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dr1

Summary

InnateDB Protein

IDBP-187801.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dr1

Protein Name

down-regulator of transcription 1

Synonyms

1700121L09Rik; Dr1l; NC2; NC2beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031190

InnateDB Gene

IDBG-187799 (Dr1)

Protein Structure

UniProt Annotation

Function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017025	TBP-class protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity