InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpsm2

Summary

InnateDB Protein

IDBP-187813.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpsm2

Protein Name

G-protein signalling modulator 2 (AGS3-like, C. elegans)

Synonyms

6230410J09Rik; LGN; Pins;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029482

InnateDB Gene

IDBG-187811 (Gpsm2)

Protein Structure

UniProt Annotation

Function

Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Note=Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in many tissues, but its expression is enriched in the ventricular zone of the developing central nervous systems.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005092	GDP-dissociation inhibitor activity
GO:0005515	protein binding
GO:0030695	GTPase regulator activity
GO:0042802	identical protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0050790	regulation of catalytic activity
GO:0060487	lung epithelial cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005938	cell cortex
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:1923373

InterPro

IPR001440 Tetratricopeptide TPR1
IPR003109 GoLoco motif
IPR011717 Tetratricopeptide TPR-4
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF02188
PF07721
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00390
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VDU0