Version 5.4
Mus musculus Protein: Pde6b
Summary
InnateDB Protein IDBP-187890.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde6b
Protein Name phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Synonyms Pdeb; r; rd; rd-1; rd1; rd10;
Species Mus musculus
Ensembl Protein ENSMUSP00000031456
InnateDB Gene IDBG-187888 (Pde6b)
Protein Structure
UniProt Annotation
Function This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
Subcellular Localization Membrane; Lipid-anchor.
Disease Associations Note=Defects in Pde6b are the cause of retinal degeneration.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0009583 detection of light stimulus
GO:0046037 GMP metabolic process
GO:0051480 cytosolic calcium ion homeostasis
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:97525
InterPro IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003018 GAF domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
IPR029016 GAF domain-like
PFAM PF00233
PF01590
PF13185
PF13492
PRINTS PR00387
PIRSF
SMART SM00065
SM00471
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23440
PhosphoSite PhosphoSite-P23440
TrEMBL Q8CA78
UniProt Splice Variant
Entrez Gene 18587
UniGene Mm.1372
RefSeq NP_032832
MGI ID
MGI Symbol Pde6b
OMIM
CCDS CCDS19510
HPRD
IMGT
EMBL AK039397 AK044364 BC062209 CH466529 X55968 X60133
GenPept AAH62209 BAC30338 BAC31885 CAA39439 CAA42719 EDL20122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca