InnateDB Protein
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IDBP-187972.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Agrp
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Protein Name
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agouti related protein
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Synonyms
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Agrt; Art;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000005849
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InnateDB Gene
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IDBG-187970 (Agrp)
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Protein Structure
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Function |
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity (By similarity). It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted. Golgi apparatus lumen {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:892013
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InterPro |
IPR007733
Agouti
IPR027300
Agouti domain
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PFAM |
PF05039
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PRINTS |
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PIRSF |
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SMART |
SM00792
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TIGRFAMs |
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Modification |
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SwissProt |
P56473
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q5J6B1
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UniProt Splice Variant |
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Entrez Gene |
11604
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UniGene |
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RefSeq |
NP_031453
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MGI ID |
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MGI Symbol |
Agrp
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OMIM |
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CCDS |
CCDS22605
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HPRD |
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IMGT |
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EMBL |
AK138796
AY497379
BC079902
CH466525
U89484
U89486
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GenPept |
AAB68620
AAB68622
AAH79902
AAS77295
BAE23781
EDL11287
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