Version 5.4
Mus musculus Gene: Agrp
Summary
InnateDB Gene IDBG-187970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agrp
Gene Name agouti related protein
Synonyms Agrt; Art
Species Mus musculus
Ensembl Gene ENSMUSG00000005705
Encoded Proteins
IDBP-187972
agouti related protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105566700-105568298
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000005849 ENSMUSP00000005849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005184 neuropeptide hormone activity
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0008343 adult feeding behavior
GO:0009648 photoperiodism
GO:0009755 hormone-mediated signaling pathway
GO:0032868 response to insulin
GO:0042755 eating behavior
GO:0060135 maternal process involved in female pregnancy
GO:0060259 regulation of feeding behavior
GO:2000253 positive regulation of feeding behavior
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159723
View Gene Order
ENSBTAG00000014556
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
syndecan_3_pathway
Syndecan-3-mediated signaling events
Cross-References
SwissProt P56473
TrEMBL Q3UU47 Q5J6B1
UniProt Splice Variant
Entrez Gene 11604
UniGene
RefSeq NM_001271806 NM_007427
OMIM
CCDS CCDS22605
HPRD
IMGT
MGI ID MGI:892013
MGI Symbol Agrp
EMBL AK138796 AY497379 BC079902 CH466525 U89484 U89486
GenPept AAB68620 AAB68622 AAH79902 AAS77295 BAE23781 EDL11287
RNA Seq Atlas 11604

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca