Version 5.4
Mus musculus Protein: Cnpy3
Summary
InnateDB Protein IDBP-188347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnpy3
Protein Name canopy 3 homolog (zebrafish)
Synonyms 1600025D17Rik; 2410050O22Rik; AI413153; CAG4A; ERDA5; PRAT4A; Tnrc5;
Species Mus musculus
Ensembl Protein ENSMUSP00000050309
InnateDB Gene IDBG-188345 (Cnpy3)
Protein Structure
UniProt Annotation
Function Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses. {ECO:0000269PubMed:16849487, ECO:0000269PubMed:17998391, ECO:0000269PubMed:20865800}.
Subcellular Localization Endoplasmic reticulum {ECO:0000269PubMed:17998391, ECO:0000269PubMed:20865800}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0045087 innate immune response
Cellular Component
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID MGI:1919279
InterPro IPR021852 Domain of unknown function DUF3456
PFAM PF11938
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DAU1
PhosphoSite PhosphoSite-Q9DAU1
TrEMBL
UniProt Splice Variant
Entrez Gene 72029
UniGene Mm.240325
RefSeq NP_082341
MGI ID
MGI Symbol Cnpy3
OMIM
CCDS CCDS28839
HPRD
IMGT
EMBL AF361644 AK005532 AK031742 AK049358 AK082340 AK082749 AK085617 AK086940 AK143428 AK220209 BC013549
GenPept AAH13549 AAK52494 BAB24103 BAC27534 BAC33707 BAC38471 BAC38599 BAC39489 BAC39769 BAD90134 BAE25373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca