Version 5.4
Mus musculus Gene: Cnpy3
Summary
InnateDB Gene IDBG-188345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnpy3
Gene Name canopy 3 homolog (zebrafish)
Synonyms 1600025D17Rik; 2410050O22Rik; AI413153; CAG4A; ERDA5; PRAT4A; Tnrc5
Species Mus musculus
Ensembl Gene ENSMUSG00000023973
Encoded Proteins
IDBP-188347
canopy 3 homolog (zebrafish)
IDBP-400718
canopy 3 homolog (zebrafish)
IDBP-535132
canopy 3 homolog (zebrafish)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18780723
[Homo sapiens] CNPY3 differentially interacts with TLR2, TLR4, and TLR9 and a single-nucleotide change in the CNPY3 gene can influence the strength of TLR responses and may also alter the relative activity of each TLR.
PMID 17998391
[Homo sapiens] CNPY3 (PRAT4A) is required for TLR-dependent immune responses where it regulates the subcellular distribution and response of multiple TLRs, required for both innate and adaptive immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137161:
PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression (Wakabayashi et al., 2006 [PubMed 16849487]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:46735705-46752214
Strand Reverse strand
Band C
Transcripts
ENSMUST00000059844 ENSMUSP00000050309
ENSMUST00000121671 ENSMUSP00000113350
ENSMUST00000129200 ENSMUSP00000120790
ENSMUST00000145877
ENSMUST00000148656
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0045087 innate immune response
Cellular Component
GO:0005783 endoplasmic reticulum
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137161
View Gene Order
ENSBTAG00000015900
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198976
Trafficking and processing of endosomal TLR pathway
REACT_230745
Immune System pathway
REACT_251547
Toll-Like Receptors Cascades pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118632
Trafficking and processing of endosomal TLR pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.240325
RefSeq NM_028065 XM_006524957 XM_006524958 XM_006524959
OMIM
CCDS CCDS28839
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca