InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd4

Summary

InnateDB Protein

IDBP-188353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd4

Protein Name

CD4 antigen

Synonyms

L3T4; Ly-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024044

InnateDB Gene

IDBG-188351 (Cd4)

Protein Structure

UniProt Annotation

Function

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	4 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001816	cytokine production
GO:0006948	induction by virus of host cell-cell fusion
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0030217	T cell differentiation
GO:0032507	maintenance of protein location in cell
GO:0042110	T cell activation
GO:0045058	T cell selection
GO:0045234	protein palmitoleylation
GO:0045860	positive regulation of protein kinase activity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829	defense response to Gram-negative bacterium
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050863	regulation of T cell activation
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:88335

InterPro

IPR000973 T-cell surface antigen CD4
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR008424 Immunoglobulin C2-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR015274 CD4, extracellular
IPR021963 T cell CD4 receptor C-terminal region

PFAM

PF05790
PF07686
PF00047
PF09191
PF12104

PRINTS

PR00692

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt