Version 5.4
Mus musculus Gene: Cd4
Summary
InnateDB Gene IDBG-188351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd4
Gene Name CD4 antigen
Synonyms L3T4; Ly-4
Species Mus musculus
Ensembl Gene ENSMUSG00000023274
Encoded Proteins
IDBP-188353
CD4 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010610:
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:124864692-124888221
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000024044 ENSMUSP00000024044
ENSMUST00000145977
ENSMUST00000145818
ENSMUST00000151594
ENSMUST00000130378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 4 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001816 cytokine production
GO:0006948 induction by virus of host cell-cell fusion
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0030217 T cell differentiation
GO:0032507 maintenance of protein location in cell
GO:0042110 T cell activation
GO:0045058 T cell selection
GO:0045234 protein palmitoleylation
GO:0045860 positive regulation of protein kinase activity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050863 regulation of T cell activation
GO:0050870 positive regulation of T cell activation
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000010610
View Gene Order
ENSBTAG00000003255
Not yet available
Pathways
NETPATH
REACTOME
REACT_199049
Defensins pathway
REACT_263643
PD-1 signaling pathway
REACT_239142
Innate Immune System pathway
REACT_216080
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_225145
Downstream TCR signaling pathway
REACT_260145
Alpha-defensins pathway
REACT_230745
Immune System pathway
REACT_215414
Translocation of ZAP-70 to Immunological synapse pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_229531
Adaptive Immune System pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_222648
TCR signaling pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04612
Antigen processing and presentation pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05340
Primary immunodeficiency pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_115574
Alpha-defensins pathway
REACT_115846
Defensins pathway
REACT_12555
Downstream TCR signaling pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_12596
Translocation of ZAP-70 to Immunological synapse pathway
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_11166
Nef Mediated CD4 Down-regulation pathway
REACT_9031
Vpu mediated degradation of CD4 pathway
REACT_6903
Binding and entry of HIV virion pathway
REACT_6266
Early Phase of HIV Life Cycle pathway
REACT_12526
TCR signaling pathway
REACT_6802
Innate Immune System pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04612
Antigen processing and presentation pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
il12_2pathway
IL12-mediated signaling events
il12_stat4pathway
IL12 signaling mediated by STAT4
hes_heypathway
Notch-mediated HES/HEY network
arf_3pathway
Arf1 pathway
cmyb_pathway
C-MYB transcription factor network
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2209
RefSeq NM_013488
OMIM
CCDS CCDS20535
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca