InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pard6a

Summary

InnateDB Protein

IDBP-188418.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pard6a

Protein Name

par-6 (partitioning defective 6,) homolog alpha (C. elegans)

Synonyms

0710008C04Rik; 2610010A15Rik; Par-6; PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090886

InnateDB Gene

IDBG-188416 (Pard6a)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269PubMed:15761148}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 at epithelial tight junctions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0007049	cell cycle
GO:0030010	establishment of cell polarity
GO:0045217	cell-cell junction maintenance
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0030054	cell junction
GO:0043234	protein complex
GO:0045177	apical part of cell