InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc6a15

Summary

InnateDB Protein

IDBP-188452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a15

Protein Name

solute carrier family 6 (neurotransmitter transporter), member 15

Synonyms

AA536730; AI326450; AI326451; v7-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073829

InnateDB Gene

IDBG-188450 (Slc6a15)

Protein Structure

UniProt Annotation

Function

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Significant expressed in brain, lung and kidney. regions, the cortex, the cerebellum and the brain stem. {ECO:0000269PubMed:16185194}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005298	proline:sodium symporter activity
GO:0005328	neurotransmitter:sodium symporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0006836	neurotransmitter transport
GO:0015804	neutral amino acid transport
GO:0015820	leucine transport
GO:0015824	proline transport
GO:0035524	proline transmembrane transport