InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sp7

Summary

InnateDB Protein

IDBP-188592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sp7

Protein Name

Sp7 transcription factor 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077596

InnateDB Gene

IDBG-188590 (Sp7)

Protein Structure

UniProt Annotation

Function

Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. {ECO:0000269PubMed:11792318}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11792318}.

Disease Associations

Tissue Specificity

Osteoblast/chondrocyte specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0017151	DEAD/H-box RNA helicase binding
GO:0046872	metal ion binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060218	hematopoietic stem cell differentiation
GO:2000738	positive regulation of stem cell differentiation