Version 5.4
Mus musculus Gene: Sp7
Summary
InnateDB Gene IDBG-188590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sp7
Gene Name Sp7 transcription factor 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000060284
Encoded Proteins
IDBP-188592
Sp7 transcription factor 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170374:
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:102356609-102366325
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000078508 ENSMUSP00000077596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0017151 DEAD/H-box RNA helicase binding
GO:0046872 metal ion binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060218 hematopoietic stem cell differentiation
GO:2000738 positive regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170374
View Gene Order
ENSBTAG00000033292
Not yet available
Cross-References
SwissProt Q8VI67
TrEMBL Q2KHK9 Q5RM08
UniProt Splice Variant
Entrez Gene 170574
UniGene Mm.263284
RefSeq NM_130458 XM_006520518 XM_006520519 XM_006520520
OMIM
CCDS CCDS37228
HPRD
IMGT
MGI ID MGI:2153568
MGI Symbol Sp7
EMBL AF184902 AK032521 AK076229 AK077375 AY803733 BC113150 CH466550
GenPept AAI13151 AAL60067 AAV66509 BAC27908 BAC36263 BAC36774 EDL03986
RNA Seq Atlas 170574

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca