InnateDB Protein
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IDBP-188707.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Actr3
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Protein Name
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ARP3 actin-related protein 3 homolog (yeast)
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Synonyms
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1200003A09Rik; Arp3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027579
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InnateDB Gene
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IDBG-188705 (Actr3)
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Protein Structure
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Function |
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
33 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921367
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InterPro |
IPR004000
Actin-related protein
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PFAM |
PF00022
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PRINTS |
PR00190
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PIRSF |
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SMART |
SM00268
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TIGRFAMs |
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Modification |
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SwissProt |
Q99JY9
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PhosphoSite |
PhosphoSite-Q99JY9
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TrEMBL |
Q9ERF8
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UniProt Splice Variant |
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Entrez Gene |
74117
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UniGene |
Mm.489246
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RefSeq |
NP_001192315
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MGI ID |
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MGI Symbol |
Actr3
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OMIM |
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CCDS |
CCDS15242
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HPRD |
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IMGT |
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EMBL |
AF307855
AK004554
AK083343
AK145536
AK147931
AK150487
AK150589
AK153079
AK153150
AK153204
AK159135
AK159775
AK160047
AK166529
AK166586
AK167148
AK167891
BC005557
BC080806
BC108386
CH466520
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GenPept |
AAG27726
AAH05557
AAH80806
AAI08387
BAB23368
BAC38876
BAE26491
BAE28238
BAE29603
BAE29683
BAE31704
BAE31760
BAE31804
BAE34847
BAE35360
BAE35589
BAE38833
BAE38875
BAE39291
BAE39903
EDL39778
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